sofosbuvir form6
PSI 7977
CAS: 1190307-88-0;1064684-44-1
Molecular Formula: C22H29FN3O9P
sofosbuvir form6 - Names and Identifiers
sofosbuvir form6 - Physico-chemical Properties
| Molecular Formula | C22H29FN3O9P |
| Molar Mass | 529.45 |
| Density | 1.41 |
| Melting Point | 122-124°C |
| Solubility | DMSO |
| Appearance | Solid |
| Color | White |
| pKa | 9.39±0.10(Predicted) |
| Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| In vitro study | As a HCV NS5B polymerase inhibitor, PSI-7977 inhibited HCV RNA replication more effectively than PSI-7976, with EC50 of 92 nM and 1.07 μm, respectively, EC90 is 0.29 μm and 2.99 μm respectively. Correspondingly, clone A cells are incubated with PSI-7977, which is better than clone A cells incubated with PSI-7976, higher concentrations of PSI-7409 were produced. PSI-7977 is an effective substrate for CatA, forming PSI-352707, which is more than 30 times more effective than PSI-7976. The S282T NS5B polymerase mutant but not the S96T mutant was resistant to PSI-7977, and EC90 was increased from 0.42 μm to 7.8 μm. In the 8-day cytotoxicity assay, PSI-7977 was not toxic to Huh7, HepG2, BxPC3, and CEM cells, even at concentrations as high as 100 μm. PSI-7977 treatment of HepG2 cells for 14 days inhibited mtDNA and rDNA with IC90 of 72.1 μm and 68.6 μm, respectively. PSI-7977 potently inhibited replication of genotypes (GT) 1a, 1b, and 2a, as well as chimeric replication containing GT 2a, 2b, and 3a NS5B polymerases. JFH-1 sequence analysis of the NS5B region illustrates the selection of other amino acid changes before and after the appearance of S282T, including T179A, M289L, I293L, M434T, and H479P, required to resist PSI-7977. |
sofosbuvir form6 - Risk and Safety
| HS Code | 29339900 |
sofosbuvir form6 - Introduction
Sofosbuvir (PSI-7977, GS-7977) is an NS5B polymerase inhibitor of HCV, which is used to treat chronic hepatitis C virus (HCV) infection.
Last Update：2022-10-16 17:12:30
Supplier List
Featured ProductsSpot supply
Product Name: Sofosbuvir Visit Supplier Webpage Request for quotationCAS: 1190307-88-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple SpecificationsSpot supply
Product Name: Sofosbuvir Request for quotationCAS: 1190307-88-0
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Sofosbuvir Visit Supplier Webpage Request for quotationCAS: 1190307-88-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: GS-7977; PSI-7977 Visit Supplier Webpage Request for quotationCAS: 1190307-88-0
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: sofosbuvir Visit Supplier Webpage Request for quotationCAS: 1190307-88-0
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Product Name: PSI 7977 Request for quotation
CAS: 1190307-88-0
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 1190307-88-0
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Spot supply
Product Name: Sofosbuvir Visit Supplier Webpage Request for quotationCAS: 1190307-88-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: Sofosbuvir Visit Supplier Webpage Request for quotationCAS: 1190307-88-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple SpecificationsSpot supply
Product Name: Sofosbuvir Request for quotationCAS: 1190307-88-0
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Sofosbuvir Visit Supplier Webpage Request for quotationCAS: 1190307-88-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: GS-7977; PSI-7977 Visit Supplier Webpage Request for quotationCAS: 1190307-88-0
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: sofosbuvir Visit Supplier Webpage Request for quotationCAS: 1190307-88-0
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Product Name: PSI 7977 Request for quotation
CAS: 1190307-88-0
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 1190307-88-0
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Spot supply
Product Name: Sofosbuvir Visit Supplier Webpage Request for quotationCAS: 1190307-88-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History